Et profilbilde

Professor
Peter Ruoff { "honorific-suffix": "Professor", "fn": "Peter Ruoff", "tel": "Telephone: +47 51831887", "email": "peter.ruoff@uis.no" }

Faculty Faculty of Science and Technology
Department Department of Chemistry and Bioscience
Room I8 D-209

 

Research fields

 

Selected publications

 

Research in progress

I am a physical chemist at the University of Stavanger with interest in reaction kinetics of chemical and biological systems and some industry related research.

After an chemical eduction at the CHF in Stuttgart and studies at the University of Oslo, I have since 1984 been in Stavanger and work on chemical and biological oscillators; especially with the BZ reaction and circadian rhythms. The BZ reaction is a chemical oscillator that can show concentration oscillations, sometimes for hours, even in a simple beaker. Apart from oscillatory behavior, chemical oscillators show a variety of surprising (and quite fascinating!) phenomena that normally are associated with biological systems; for example excitability, bistability, chemical pulse propagation and spontaneous structure or pattern formation. Even chaos can be observed. I have expertise in enzyme kinetics and study dynamics and properties as well as temperature compensation of circadian clocks. In these studies the fungus Neurospora crassa is used as a model organism. I also work on an systems biology approach how metabolic pathways adapt to changing environmental conditions. Presently I participate in two (1,2) EU (SysMO) projects financed by the Norwegian FUGE programme with focus on temperature.

In industry-related projects we have studied precipitation kinetics of gas hydrates, polymer crosslinking as well as applying NMR and fluorescence spectroscopy to various problems in offshore industry. In cooperation with food research institutes we have been using PCR and RT-PCR techniques for rapid identification of toxic gene products from contaminating microorganisms in foods.

Please go to this site for further information.

Work experience

 

Scientific publications (from Cristin)

  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (2015). Controller Motifs for Homeostatic Regulation and Their Applications in Biological Systems. Universitetet i Stavanger. ISBN 978-82-7644-628-9. 300 p.
  • Brattland, Vegard; Austvoll, Ivar; Ruoff, Peter; Drengstig, Tormod (2017). Image processing of leaf movements in Mimosa pudica. 2017-06-12 - 2017-06-14.
  • Fjeld, Gunhild; Ruoff, Peter; Drengstig, Tormod (2017). Different Implementations of Integral Control Affect Controller Performances During Time-Dependent Perturbations. Cold Spring Harbor laboratory; 2017-04-11 - 2017-04-14.
  • Omdal, Roald; Larssen, E.; Brede, Cato; Hjelle, Anne; Tjensvoll, A.B.; Norheim, K. B.; Bårdsen, Kjell; Jonsdottir, Kristin; Ruoff, Peter; Nilsen, M. M. (2017). A Proteomic Signature of Fatigue in Primary Sjögren's Syndrome. 2017-06-14 - 2017-06-17.
  • Ruoff, Peter (2017). Nobelpris i Fysiologi 2017. Norsk Kjemisk Selskap Stavanger Avdeling;
  • Ruoff, Peter (2017). The Kinetics of Biological Control. University of South Bohemia;
  • Ruoff, Peter (2017). The Kinetics of Biological Control. Digital Life Norway;
  • Thorsen, Kristian; Risvoll, Geir; Tveit, Daniel Myklatun; Ruoff, Peter; Drengstig, Tormod (2016). Tuning of Physiological Controller Motifs. 2016-09-12 - 2016-09-16.
  • Agafonov, Oleg; Selstø, Christina Helen; Thorsen, Kristian; Xu, Xiang Ming; Drengstig, Tormod; Ruoff, Peter (2015). The Organization of Controller Motifs Leading to Robust Plant Iron Homeostasis. The French Society of Plant Biologists; 2015-07-05 - 2015-07-09.
  • Larssen, Eivind; Brede, C; Hjelle, Anne; Øysæd, Kjell Birger; Tjensvoll, A.B.; Norheim, Katrine Brække; Bårdsen, Kjersti; Ruoff, Peter; Omdal, Roald; Nilsen, M.M. (2015). Fatigue in Primary Sjögrens Syndrome : A Proteomic Study of Cerebrospinal Fluid.
  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter; Gundersen, Ina (2015). Nytt sykehus Ullandhaug - Jubler for plasseringen. Stavanger Aftenblad. [Newspaper]; 2015-11-28.
  • Drengstig, Tormod; Jolma, Ingunn Westvik; Thorsen, Kristian; Ruoff, Peter (2013). Fysiologiske reguleringsmekanismer.
  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (2013). Integrative modeling of glucose transport and homeostasis in enterocytes. Cold Spring Harbor Laboratory; 2013-03-19 - 2013-03-22.
  • Kitanovic, Ana; Bonowski, Felix; Heigwer, Florian; Ruoff, Peter; Kitanovic, Igor; Ungewiss, Christin; Wölfl, Stefan (2012). Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5.
  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (2012). Modeling and simulation of intestinal nutrient uptake. The International Society for Systems Biology; 2012-08-19 - 2012-08-23.
  • Jolma, Ingunn Westvik; Lillo, Cathrine; Ruoff, Peter (2011). Temperature dependence of rutin-Fe(II) binding constants determined by isothermal titration calorimetry. SPPS; 2011-08-20 - 2011-08-25.
  • Ruoff, Peter (2011). A complete set of robust homeostatic network motifs and their oscillatory behaviors. 2011-03-29 - 2011-04-01.
  • Ruoff, Peter (2011). Integrating Fluctuating Nitrate Uptake And Assimilation Rates To Robust Cytosolic Nitrate Homeostasis. 2011-09-14 - 2011-09-16.
  • Ruoff, Peter (2011). Molecular Mechanisms for Homeostatic Controllers and Perfect Adaptation. 2011-11-11.
  • Ruoff, Peter (2011). Network motifs leading to plant nitrate homeostasis and oscillatory nitrate assimilation. 2011-08-22 - 2011-08-25.
  • Ruoff, Peter (2011). Vår indre biologiske klokke.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Kitanovic, Ana; Bonowski, Felix; Ruoff, Peter; Kitanovic, Igor; Heigwer, F.; Wölfl, Stefan (2010). Computer controlled automated assay for comprehensive studies of S.cerevisiae growth kinetic in response to extracellular conditions.
  • Ruoff, Peter (2010). Homeostatic and Oscillatory Mechanisms in Plant and Fungal Nitrate Assimilation. 2010-10-25 - 2010-10-29.
  • Ruoff, Peter (2010). Molecular Mechanisms for Homeostatic Controllers and Perfect Adaptation. Systems Biology Group, University of Manchester; 2010-05-11.
  • Ruoff, Peter (2010). Rhythmen der Natur. [Newspaper]; 2010-04-01.
  • Ruoff, Peter (2009). Homeostatic controllers: robustness, temperature behaviors and oscillatory responses. Systems Biology Group, Harvard Medical School; 2009-10-16.
  • Johansen, Øystein; Ryen, Tom; Eftestøl, Trygve; Kjosmoen, Thomas; Ruoff, Peter (2008). Splice Site Prediction using Artificial Neural Networks. 2008-10-03 - 2008-10-04.
  • Ruoff, Peter (2008). Perfect Adaptation and Temperature Compensation in Reaction Kinetic Networks. 2008-03-26 - 2008-03-30.
  • Ruoff, Peter (2008). Temperature Compensation and Adaptation Mechanisms in Circadian Rhythms and Reaction Kinetic Networks. National Institute of Nutrition and Seafood Research; 2008-11-18.
  • Ruoff, Peter (2008). Temperature Compensation and Adaptation Mechanisms in Reaction Kinetic Networks. Department of Systems Biology & Bioinformatics, University of Rostock; 2008-08-11 - 2008-08-12.
  • Ruoff, Peter (2007). Chemical Oscillations and Circadian Rhythms. 2007-07-02 - 2007-08-10.
  • Ruoff, Peter (2007). How Do Cells Compute?. 2007-07-02 - 2007-08-10.
  • Ruoff, Peter (2007). Perfect Adaptation with Zero Control Coefficients. 2007-07-02 - 2007-08-10.
  • Eftestøl, Trygve; Ryen, Tom; Aase, Sven Ole; Strässle, Cassian; Boos, Marcus; Schuster, Guido M.; Ruoff, Peter (2006). Eukaryotic gene prediction by spectral analysis and pattern recognition techniques. 2006-06-07 - 2006-06-09.
  • Hong, Christian; Jolma, Ingunn; Loros, Jennifer J.; Dunlap, Jay C.; Ruoff, Peter (2006). A Mathematical Model of Neurospora crassa Circadian Rhythms. 2006-05-21 - 2006-05-25.
  • Mehra, Arun; Shi, Mi; Hong, Christian; Ruoff, Peter; Loros, Jennifer J.; Dunlap, Jay C. (2006). Genes Involved in Temperature Compensation of the N. crassa Clock. 2006-05-21 - 2006-05-25.
  • Ruoff, Peter (2006). Modelling the Neurospora Circadian Clock. 2006-05-21 - 2006-05-25.
  • Ruoff, Peter (2006). The Neurospora Circadian Clock: Modeling and Experiments. 2006-04-08 - 2006-04-11.
  • Ruoff, Peter (2006). The Neurospora Circadian Clock: Modelling and Experiments. 2006-04-11.
  • Zakhartsev, Maxim; Ruoff, Peter (2006). Metabolic Temperature Compensation of Metabolic Flux in Yeast S. cerevisiae. 2006-06-18.
  • Ruoff, Peter (2005). A Nitrate-Induced FRQ-less Oscillator in Neurospora crassa. 2005-03-15 - 2005-03-20.
  • Ruoff, Peter (2005). Modelling temperature effects on circadian clocks. 2005-07-18 - 2005-07-22.
  • Ruoff, Peter (2005). Molecular Bases of Temperature Compensation in Biochemical Oscillators and Physiological Clocks. Norwegian University of Life Sciences; 2005-05-30.
  • Ruoff, Peter (2005). Molecular Basis of Temperature Compensation in Biochemical Oscillators and Physiological Clocks. International University Bremen; 2005-02-02.
  • Ruoff, Peter (2005). PER/TIM-mediated amplification, gene dosage effects and temperature compensation in the two- loop model of the Drosophila circadian clock. 2005-07-18 - 2005-07-22.
  • Ruoff, Peter (2005). Studier og forskning i Biologisk kjemi ved Universitetet i Stavanger. 2005-11-23.
  • Ruoff, Peter (2004). Bioteknologi - et fagfelt i rask utvikling. Sandnes museum og vitensenter; 2004-04-25.
  • Ruoff, Peter (2004). Den biologiske klokken og organismenes tilpasning til det ytre miljø:Mekanismer og modeller for temperaturkompensasjon i circadiane rytmer Temperaturadaptasjon i Organismer. Høgskolen i Stavanger; 2004-10-29.
  • Ruoff, Peter (2004). Temperature Effects on Circadian Clocks Temperature Compensation in Circadian Clocks. 2004-10-10 - 2004-10-15.
  • Ruoff, Peter (2004). The Neurospora Circadian Clock: Models and Experiments. University of Warwick, Department of Mathematics; 2004-03-02 - 2004-03-03.
  • Ruoff, Peter (2004). The Role of the PER/TIM Complex on the Stability of Oscillations in a Model of the Drosophila Circadian Clock. 2004-04-01 - 2004-04-04.
  • Ruoff, Peter (2003). A Theory for Temperature-Compensation and Period Homeostasis in Reaction Kinetic Models of Biological Oscillators. 2003-03-24 - 2003-03-27.
  • Ruoff, Peter (2003). Bioteknologi - et eksploderende fagfelt. 2003-11-26.
  • Ruoff, Peter (2003). Modelling the Neurospora Circadian Clock. 2003-10-17 - 2003-10-18.
  • Ruoff, Peter (2002). The Neuorspora Circadian Clock: Model Predictions and Experiments Modelling of Circadian Rhythms. 2002-05-22 - 2002-05-26.
  • Rensing, L.; Meyer-Grahle, Ulf; Ruoff, Peter (2001). Biologische Uhren: Timing-Mechanismen in der Natur Chronobiologie.
  • Ruoff, Peter (2001). Bioteknologi - et eksploderende fagfelt. Institutt for matematikk og naturvitenskap, Avdeling for teknisk-natur; 2001-10-25.
  • Ruoff, Peter (2001). Neurospora crassa: en liten sopp brukt i forskning om biologiske klokker. [Radio]; 2001-12-02.
  • Ruoff, Peter (2001). Simulating the Effect of Light Pulses on the Sporulation Rhythm of Neurospora crassa. 2001-09-03 - 2001-09-08.
  • Ruoff, Peter (2001). Temperature-Compensation and General Homeostasis in Physiological Clocks: Theory, Experiments and the Importance of Clock Protein Degradation. 2001-06-24 - 2001-06-30.
  • Ruoff, Peter (2001). The Neurospora crassa clock: The Importance of the frequency Gene for both Temperature-Compensation and pH-Homeostasis. 2001-08-05 - 2001-08-10.
  • Ruoff, Peter (2000). Discrepancies between "new" and "old" Oregonator Rate Constants: Comparisons between experimental and theoretical Phase Response Curves of Bromide-Ion Perturbations.
  • Ruoff, Peter (2000). Modeling of Temperature Compensation in Circadian Rhythms. Workshop on Biomathematical Models of Circadian Rhythmicity, Sleep Regulation and Neurobehavioral Function in Humans.
  • Ruoff, Peter (2000). Models of Temperature Compensation in Biological Rhythms.
  • Ruoff, Peter (2000). Temperature Compensation in Biological Rhythms.
  • Ruoff, Peter (2000). Temperature-Compensated Biochemical Systems: Circadian Clocks Biochemical Oscillators. NTNU; 2000-09-21.
  • Jakobsen, Thorvald; Ruoff, Peter (1999). Clathrate Hydrate Formation in Water-in-Oil Emulsions - A Kinetic Study of the Model System Trichlorofluoromethane and Model Oil/Water/Nonionic Surfactant by Means of Dielectric Spectroscopy.
  • Körös, Endre; Kurin-Csörgei, Krisztina; Nagy, Gabriella; Ruoff, Peter; da Silva, Manuel A. V. Ribeir (1999). Temperature dependence on activation energies of catalyzed, uncatalyzed, and perturbed bromate oscillators. A search for temperature-compensated ch oscillators.
  • Lillo, Cathrine; Kazazic, Sabina; Ruoff, Peter; Meyer, C. (1999). Regulation of nitrate reductase in light and darkness, effects of a signalling protein.
  • Ruoff, Peter (1999). Photoluminescence in the Oscillatory Ce-ion catalyzed Belousov-Zhabotinsky Reaction.
  • Ruoff, Peter (1999). Photoluminescence in the Oscillatory Ru-ion-catalyzed Belousov-Zhabotinsky Reaction.
  • Ruoff, Peter; da Silva, Manuel A. V. Ribeir (1999). Temperature Compensation in Models of Biological and Chemical Oscillators.
  • Ruoff, Peter; Touitou, Yvan (1999). Models of Temperature Compensation in Biological Rhythms.
  • Vinsjevik, Merete; Monnerjahn, Christian; Rensing, Ludger; Ruoff, Peter (1999). The Neurospora clock: frq-mRNA measured by quantitative RT-PCR.
  • Ruoff, Peter (1998). Dynamics of Chemical Oscillatory Processes.
  • Ruoff, Peter (1998). Temperature-Compensation by Random Walk.
  • Ruoff, Peter; Rensing, L. (1998). Phase Resetting and Entrainment by Temperature Pertubations in a Temperature-Compensated Oscillator Model with negative Feedback.
  • Ruoff, Peter; Rensing, L. (1998). Phase Resetting and Entrainment by Temperature Perturbations in a Temperature-Compensated Oscillator model with negative Feedback.
  • Vinsjevik, Merete; Ruoff, Peter; Jørgensen, Per M.; Botnen, Astri (1998). Den molekylære mekanismen til den biologiske klokken.
  • Lekvam, Knut; Ruoff, Peter (1996). Temperature Hysteresis of Methane Hydrate Formation and Decomposition in Liquid Water. 1996-06-02 - 1996-06-06.
  • Ruoff, Peter (1995). Circadian Rhythms and Models of Temperature-Compensation Sirkadiske rytmer og modeller for temperaturkompensasjon. Department of Cell Biology, Biochemistry and Biotechnology, University; 1995-10-30.
  • Ruoff, Peter (1995). Models of Circadian Rhythms. University of Bremen; 1995-05-29.
  • Ruoff, Peter (1995). The Circadian Clock Models of Circadian Clocks. GKSS-Forschungszentrum Geesthacht; 1995-11-24.
  • Ruoff, Peter (1994). Temperature-Compensation by Random Walk. 1994-03-22 - 1994-03-25.
  • Lekvam, Knut; Ruoff, Peter (1993). Reaction Kinetic Simulations of Methane Hydrate Formation in Liquid Water. 1993-06-20 - 1993-06-24.
  • Ruoff, Peter (1993). Enzyme Catalyzed Reactions Enzymkatalyserte Reaksjoner. Høgskolesenteret i Rogaland; 1993-02-11.
  • Ruoff, Peter (1993). Mechanisms of Chemical Oscillatory Reactions Kjemiske oscillators mekanismer. Kjemisk institutt, Universitetet i Bergen; 1993-04-29.
  • Ruoff, Peter (1993). Oscillatory Reactions in Chemistry and Biology Oscillerende reaksjoner i kjemi og biologi. Norsk Kjemisk Selskap; 1993-04-28.
  • Ruoff, Peter (1993). Temperature-Compensation in Reaction Kinetic Models of Biological and Chemical Oscillators. Department of Cell Biology, Biochemistry and Biotechnology, University; 1993-12-03.
  • Ruoff, Peter (1993). Temperature-Compensation in any Reaction Kinetic Model of Circadian Oscillations. 1993-08-08 - 1993-08-13.