Et profilbilde

Professor
Peter Ruoff { "honorific-suffix": "Professor", "fn": "Peter Ruoff", "tel": "Telefon: 51831887", "email": "peter.ruoff@uis.no" }

Avdeling/enhet Det teknisk- naturvitenskapelige fakultet
Institutt/senter Institutt for matematikk og naturvitenskap
Rom I8 D-209
Hjemmeside http://www.ux.uis.no/~ruoff

Forskningsområder

The research in my group is directed towards the understanding of dynamics in complex chemical and biological systems, with particular interest in adaptation/decision mechanisms and homeostasis within circadian clocks and metabolic pathways/reaction kinetic networks. Our approach is multidisciplinary which involves experimental biochemical, biophysical and molecular biology techniques combined with theoretical and computational methods.

Utvalgte publikasjoner

P. Ruoff and R. M. Noyes: Bistability and Unusual Oscillatory Behavior in a Closed Belousov-Zhabotinsky Reaction System. J. Phys. Chem. 1985, 89, 1339.

P. Ruoff: Introducing Temperature-Compensation in any Reaction Kinetic Oscillator Model. J. Interdiscipl. Cycle Research 1992, 23, 92.

P. Ruoff and L. Rensing: The Temperature-Compensated Goodwin Oscillator Simulates Many Circadian Clock Properties. J. Theoret. Biol. 1996, 179, 275- 285.

P. Ruoff, A. Behzadi, M. Hauglid, M. Vinsjevik and H. Havås: pH-Homeostasis of the Circadian Sporulation Rhythm in Clock Mutants of Neurospora crassa. Chronobiol. Internat. 2000, 17, 733-750.

M. K. Christensen, G. Falkeid, J. J. Loros, J. C. Dunlap, C. Lillo, and P. Ruoff: A Nitrate-Induced frq-Less Oscillator in Neurospora crassa. J. Biol. Rhythms, 2004, 19, 280-286.

P. Ruoff, J. J. Loros and J. C. Dunlap: The relationship between FRQ-protein stability and temperature compensation in the Neurospora circadian clock. PNAS, 2005, 102, 17681-17686.

I. W. Jolma, G. Falkeid, M. Bamerni and P. Ruoff: Lithium Leads to an Increased FRQ Protein Stability and to a Partial Loss of Temperature Compensation in the Neurospora circadian clock. J. Biol. Rhythms, 2006, 21, 327-334.

T. Drengstig, H. R. Ueda, and P. Ruoff: Predicting perfect adaptation motifs in reaction kinetic networks. J. Phys. Chem. B, 2008, 112, 16752-16758.

X. Y. Ni, T. Drengstig, and P. Ruoff: The control of the controller: Molecular mechanisms for robust perfect adaptation and temperature compensation. Biophys. J., 2009, 97, 1244-1253.

I. W. Jolma, X. Y. Ni, L. Rensing, and P. Ruoff: Harmonic Oscillations in Homeostatic Controllers: Dynamics of the p53 Regulatory System. Biophys. J., 2010, 98, 743-552.

I. W. Jolma, O. D. Laerum, C. Lillo, and P. Ruoff: Circadian Oscillators in Eukaryotes. WIREs Systems Biology and Medicine, 2010. DOI: 10.1002/wsbm.81.

T. Drengstig, T. Kjosmoen, and P. Ruoff: On the Relationship between Sensitivity Coefficients and Transfer Functions of Reaction Kinetic Networks. J. Phys. Chem. B, , 2011, 115, 6272-6278; doi: 10.1021/jp200578e.

T. Drengstig, X. Y. Ni, K. Thorsen, I. W. Jolma, and P. Ruoff: Robust Adaptation and Homeostasis by Autocatalysis. J. Phys. Chem. B, 2012, 116, 5355-5363; doi: 10.1021/jp3004568I.

T. Drengstig, I. W. Jolma, X. Y. Ni, K. Thorsen, X. M. Xu, and P. Ruoff: A Basic Set of Homeostatic Controller Motifs. Biophys. J., 2012, 103, 2000-2010; doi: 10.1016/j.bpj.2012.09.033.

Y. Huang, T. Drengstig, and P. Ruoff: Integrating fluctuating nitrate uptake and assimilation to robust homeostasis. Plant, Cell & Environment, 2012, 35, 917-928; doi: 10.1111/j.1365-3040.2011.02462.x

Pågående forskning

Arbeidserfaring

Vitenskapelige publikasjoner (fra CRISTin)

  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (2015). Controller Motifs for Homeostatic Regulation and Their Applications in Biological Systems. Universitetet i Stavanger. ISBN 978-82-7644-628-9. 300 s.
  • Brattland, Vegard; Austvoll, Ivar; Ruoff, Peter; Drengstig, Tormod (2017). Image processing of leaf movements in Mimosa pudica. 2017-06-12 - 2017-06-14.
  • Omdal, Roald; Larssen, E.; Brede, Cato; Hjelle, Anne; Tjensvoll, A.B.; Norheim, K. B.; Bårdsen, Kjell; Jonsdottir, Kristin; Ruoff, Peter; Nilsen, M. M. (2017). A Proteomic Signature of Fatigue in Primary Sjögren's Syndrome. 2017-06-14 - 2017-06-17.
  • Ruoff, Peter (2017). Nobelpris i Fysiologi 2017. Norsk Kjemisk Selskap Stavanger Avdeling;
  • Ruoff, Peter (2017). The Kinetics of Biological Control. Digital Life Norway;
  • Ruoff, Peter (2017). The Kinetics of Biological Control. University of South Bohemia;
  • Thorsen, Kristian; Risvoll, Geir; Tveit, Daniel Myklatun; Ruoff, Peter; Drengstig, Tormod (2016). Tuning of Physiological Controller Motifs. 2016-09-12 - 2016-09-16.
  • Agafonov, Oleg; Selstø, Christina Helen; Thorsen, Kristian; Xu, Xiang Ming; Drengstig, Tormod; Ruoff, Peter (2015). The Organization of Controller Motifs Leading to Robust Plant Iron Homeostasis. The French Society of Plant Biologists; 2015-07-05 - 2015-07-09.
  • Larssen, Eivind; Brede, C; Hjelle, Anne; Øysæd, Kjell Birger; Tjensvoll, A.B.; Norheim, Katrine Brække; Bårdsen, Kjersti; Ruoff, Peter; Omdal, Roald; Nilsen, M.M. (2015). Fatigue in Primary Sjögrens Syndrome : A Proteomic Study of Cerebrospinal Fluid.
  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter; Gundersen, Ina (2015). Nytt sykehus Ullandhaug - Jubler for plasseringen. Stavanger Aftenblad. [Avis]; 2015-11-28.
  • Drengstig, Tormod; Jolma, Ingunn Westvik; Thorsen, Kristian; Ruoff, Peter (2013). Fysiologiske reguleringsmekanismer.
  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (2013). Integrative modeling of glucose transport and homeostasis in enterocytes. Cold Spring Harbor Laboratory; 2013-03-19 - 2013-03-22.
  • Kitanovic, Ana; Bonowski, Felix; Heigwer, Florian; Ruoff, Peter; Kitanovic, Igor; Ungewiss, Christin; Wölfl, Stefan (2012). Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5.
  • Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter (2012). Modeling and simulation of intestinal nutrient uptake. The International Society for Systems Biology; 2012-08-19 - 2012-08-23.
  • Jolma, Ingunn Westvik; Lillo, Cathrine; Ruoff, Peter (2011). Temperature dependence of rutin-Fe(II) binding constants determined by isothermal titration calorimetry. SPPS; 2011-08-20 - 2011-08-25.
  • Ruoff, Peter (2011). A complete set of robust homeostatic network motifs and their oscillatory behaviors. 2011-03-29 - 2011-04-01.
  • Ruoff, Peter (2011). Integrating Fluctuating Nitrate Uptake And Assimilation Rates To Robust Cytosolic Nitrate Homeostasis. 2011-09-14 - 2011-09-16.
  • Ruoff, Peter (2011). Molecular Mechanisms for Homeostatic Controllers and Perfect Adaptation. 2011-11-11.
  • Ruoff, Peter (2011). Network motifs leading to plant nitrate homeostasis and oscillatory nitrate assimilation. 2011-08-22 - 2011-08-25.
  • Ruoff, Peter (2011). Vår indre biologiske klokke.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Jolma, Ingunn; Ni, Xiao Yu; Kjosmoen, Thomas; Drengstig, Tormod; Ruoff, Peter; Jensen, Karene (2010). Robust Homeostatic Controllers: Molecular Mechanisms and Oscillatory Responses. 2010-03-22 - 2010-03-24.
  • Kitanovic, Ana; Bonowski, Felix; Ruoff, Peter; Kitanovic, Igor; Heigwer, F.; Wölfl, Stefan (2010). Computer controlled automated assay for comprehensive studies of S.cerevisiae growth kinetic in response to extracellular conditions.
  • Ruoff, Peter (2010). Homeostatic and Oscillatory Mechanisms in Plant and Fungal Nitrate Assimilation. 2010-10-25 - 2010-10-29.
  • Ruoff, Peter (2010). Molecular Mechanisms for Homeostatic Controllers and Perfect Adaptation. Systems Biology Group, University of Manchester; 2010-05-11.
  • Ruoff, Peter (2010). Rhythmen der Natur. [Avis]; 2010-04-01.
  • Ruoff, Peter (2009). Homeostatic controllers: robustness, temperature behaviors and oscillatory responses. Systems Biology Group, Harvard Medical School; 2009-10-16.
  • Johansen, Øystein; Ryen, Tom; Eftestøl, Trygve; Kjosmoen, Thomas; Ruoff, Peter (2008). Splice Site Prediction using Artificial Neural Networks. 2008-10-03 - 2008-10-04.
  • Ruoff, Peter (2008). Perfect Adaptation and Temperature Compensation in Reaction Kinetic Networks. 2008-03-26 - 2008-03-30.
  • Ruoff, Peter (2008). Temperature Compensation and Adaptation Mechanisms in Circadian Rhythms and Reaction Kinetic Networks. National Institute of Nutrition and Seafood Research; 2008-11-18.
  • Ruoff, Peter (2008). Temperature Compensation and Adaptation Mechanisms in Reaction Kinetic Networks. Department of Systems Biology & Bioinformatics, University of Rostock; 2008-08-11 - 2008-08-12.
  • Ruoff, Peter (2007). Chemical Oscillations and Circadian Rhythms. 2007-07-02 - 2007-08-10.
  • Ruoff, Peter (2007). How Do Cells Compute?. 2007-07-02 - 2007-08-10.
  • Ruoff, Peter (2007). Perfect Adaptation with Zero Control Coefficients. 2007-07-02 - 2007-08-10.
  • Eftestøl, Trygve; Ryen, Tom; Aase, Sven Ole; Strässle, Cassian; Boos, Marcus; Schuster, Guido M.; Ruoff, Peter (2006). Eukaryotic gene prediction by spectral analysis and pattern recognition techniques. 2006-06-07 - 2006-06-09.
  • Hong, Christian; Jolma, Ingunn; Loros, Jennifer J.; Dunlap, Jay C.; Ruoff, Peter (2006). A Mathematical Model of Neurospora crassa Circadian Rhythms. 2006-05-21 - 2006-05-25.
  • Mehra, Arun; Shi, Mi; Hong, Christian; Ruoff, Peter; Loros, Jennifer J.; Dunlap, Jay C. (2006). Genes Involved in Temperature Compensation of the N. crassa Clock. 2006-05-21 - 2006-05-25.
  • Ruoff, Peter (2006). Modelling the Neurospora Circadian Clock. 2006-05-21 - 2006-05-25.
  • Ruoff, Peter (2006). The Neurospora Circadian Clock: Modeling and Experiments. 2006-04-08 - 2006-04-11.
  • Ruoff, Peter (2006). The Neurospora Circadian Clock: Modelling and Experiments. 2006-04-11.
  • Zakhartsev, Maxim; Ruoff, Peter (2006). Metabolic Temperature Compensation of Metabolic Flux in Yeast S. cerevisiae. 2006-06-18.
  • Ruoff, Peter (2005). A Nitrate-Induced FRQ-less Oscillator in Neurospora crassa. 2005-03-15 - 2005-03-20.
  • Ruoff, Peter (2005). Modelling temperature effects on circadian clocks. 2005-07-18 - 2005-07-22.
  • Ruoff, Peter (2005). Molecular Bases of Temperature Compensation in Biochemical Oscillators and Physiological Clocks. Norwegian University of Life Sciences; 2005-05-30.
  • Ruoff, Peter (2005). Molecular Basis of Temperature Compensation in Biochemical Oscillators and Physiological Clocks. International University Bremen; 2005-02-02.
  • Ruoff, Peter (2005). PER/TIM-mediated amplification, gene dosage effects and temperature compensation in the two- loop model of the Drosophila circadian clock. 2005-07-18 - 2005-07-22.
  • Ruoff, Peter (2005). Studier og forskning i Biologisk kjemi ved Universitetet i Stavanger. 2005-11-23.
  • Ruoff, Peter (2004). Bioteknologi - et fagfelt i rask utvikling. Sandnes museum og vitensenter; 2004-04-25.
  • Ruoff, Peter (2004). Den biologiske klokken og organismenes tilpasning til det ytre miljø:Mekanismer og modeller for temperaturkompensasjon i circadiane rytmer Temperaturadaptasjon i Organismer. Høgskolen i Stavanger; 2004-10-29.
  • Ruoff, Peter (2004). Temperature Effects on Circadian Clocks Temperature Compensation in Circadian Clocks. 2004-10-10 - 2004-10-15.
  • Ruoff, Peter (2004). The Neurospora Circadian Clock: Models and Experiments. University of Warwick, Department of Mathematics; 2004-03-02 - 2004-03-03.
  • Ruoff, Peter (2004). The Role of the PER/TIM Complex on the Stability of Oscillations in a Model of the Drosophila Circadian Clock. 2004-04-01 - 2004-04-04.
  • Ruoff, Peter (2003). A Theory for Temperature-Compensation and Period Homeostasis in Reaction Kinetic Models of Biological Oscillators. 2003-03-24 - 2003-03-27.
  • Ruoff, Peter (2003). Bioteknologi - et eksploderende fagfelt. 2003-11-26.
  • Ruoff, Peter (2003). Modelling the Neurospora Circadian Clock. 2003-10-17 - 2003-10-18.
  • Ruoff, Peter (2002). The Neuorspora Circadian Clock: Model Predictions and Experiments Modelling of Circadian Rhythms. 2002-05-22 - 2002-05-26.
  • Rensing, L.; Meyer-Grahle, Ulf; Ruoff, Peter (2001). Biologische Uhren: Timing-Mechanismen in der Natur Chronobiologie.
  • Ruoff, Peter (2001). Bioteknologi - et eksploderende fagfelt. Institutt for matematikk og naturvitenskap, Avdeling for teknisk-natur; 2001-10-25.
  • Ruoff, Peter (2001). Neurospora crassa: en liten sopp brukt i forskning om biologiske klokker. [Radio]; 2001-12-02.
  • Ruoff, Peter (2001). Simulating the Effect of Light Pulses on the Sporulation Rhythm of Neurospora crassa. 2001-09-03 - 2001-09-08.
  • Ruoff, Peter (2001). Temperature-Compensation and General Homeostasis in Physiological Clocks: Theory, Experiments and the Importance of Clock Protein Degradation. 2001-06-24 - 2001-06-30.
  • Ruoff, Peter (2001). The Neurospora crassa clock: The Importance of the frequency Gene for both Temperature-Compensation and pH-Homeostasis. 2001-08-05 - 2001-08-10.
  • Ruoff, Peter (2000). Discrepancies between "new" and "old" Oregonator Rate Constants: Comparisons between experimental and theoretical Phase Response Curves of Bromide-Ion Perturbations.
  • Ruoff, Peter (2000). Modeling of Temperature Compensation in Circadian Rhythms. Workshop on Biomathematical Models of Circadian Rhythmicity, Sleep Regulation and Neurobehavioral Function in Humans.
  • Ruoff, Peter (2000). Models of Temperature Compensation in Biological Rhythms.
  • Ruoff, Peter (2000). Temperature Compensation in Biological Rhythms.
  • Ruoff, Peter (2000). Temperature-Compensated Biochemical Systems: Circadian Clocks Biochemical Oscillators. NTNU; 2000-09-21.
  • Jakobsen, Thorvald; Ruoff, Peter (1999). Clathrate Hydrate Formation in Water-in-Oil Emulsions - A Kinetic Study of the Model System Trichlorofluoromethane and Model Oil/Water/Nonionic Surfactant by Means of Dielectric Spectroscopy.
  • Körös, Endre; Kurin-Csörgei, Krisztina; Nagy, Gabriella; Ruoff, Peter; da Silva, Manuel A. V. Ribeir (1999). Temperature dependence on activation energies of catalyzed, uncatalyzed, and perturbed bromate oscillators. A search for temperature-compensated ch oscillators.
  • Lillo, Cathrine; Kazazic, Sabina; Ruoff, Peter; Meyer, C. (1999). Regulation of nitrate reductase in light and darkness, effects of a signalling protein.
  • Ruoff, Peter (1999). Photoluminescence in the Oscillatory Ce-ion catalyzed Belousov-Zhabotinsky Reaction.
  • Ruoff, Peter (1999). Photoluminescence in the Oscillatory Ru-ion-catalyzed Belousov-Zhabotinsky Reaction.
  • Ruoff, Peter; da Silva, Manuel A. V. Ribeir (1999). Temperature Compensation in Models of Biological and Chemical Oscillators.
  • Ruoff, Peter; Touitou, Yvan (1999). Models of Temperature Compensation in Biological Rhythms.
  • Vinsjevik, Merete; Monnerjahn, Christian; Rensing, Ludger; Ruoff, Peter (1999). The Neurospora clock: frq-mRNA measured by quantitative RT-PCR.
  • Ruoff, Peter (1998). Dynamics of Chemical Oscillatory Processes.
  • Ruoff, Peter (1998). Temperature-Compensation by Random Walk.
  • Ruoff, Peter; Rensing, L. (1998). Phase Resetting and Entrainment by Temperature Pertubations in a Temperature-Compensated Oscillator Model with negative Feedback.
  • Ruoff, Peter; Rensing, L. (1998). Phase Resetting and Entrainment by Temperature Perturbations in a Temperature-Compensated Oscillator model with negative Feedback.
  • Vinsjevik, Merete; Ruoff, Peter; Jørgensen, Per M.; Botnen, Astri (1998). Den molekylære mekanismen til den biologiske klokken.
  • Lekvam, Knut; Ruoff, Peter (1996). Temperature Hysteresis of Methane Hydrate Formation and Decomposition in Liquid Water. 1996-06-02 - 1996-06-06.
  • Ruoff, Peter (1995). Circadian Rhythms and Models of Temperature-Compensation Sirkadiske rytmer og modeller for temperaturkompensasjon. Department of Cell Biology, Biochemistry and Biotechnology, University; 1995-10-30.
  • Ruoff, Peter (1995). Models of Circadian Rhythms. University of Bremen; 1995-05-29.
  • Ruoff, Peter (1995). The Circadian Clock Models of Circadian Clocks. GKSS-Forschungszentrum Geesthacht; 1995-11-24.
  • Ruoff, Peter (1994). Temperature-Compensation by Random Walk. 1994-03-22 - 1994-03-25.
  • Lekvam, Knut; Ruoff, Peter (1993). Reaction Kinetic Simulations of Methane Hydrate Formation in Liquid Water. 1993-06-20 - 1993-06-24.
  • Ruoff, Peter (1993). Enzyme Catalyzed Reactions Enzymkatalyserte Reaksjoner. Høgskolesenteret i Rogaland; 1993-02-11.
  • Ruoff, Peter (1993). Mechanisms of Chemical Oscillatory Reactions Kjemiske oscillators mekanismer. Kjemisk institutt, Universitetet i Bergen; 1993-04-29.
  • Ruoff, Peter (1993). Oscillatory Reactions in Chemistry and Biology Oscillerende reaksjoner i kjemi og biologi. Norsk Kjemisk Selskap; 1993-04-28.
  • Ruoff, Peter (1993). Temperature-Compensation in Reaction Kinetic Models of Biological and Chemical Oscillators. Department of Cell Biology, Biochemistry and Biotechnology, University; 1993-12-03.
  • Ruoff, Peter (1993). Temperature-Compensation in any Reaction Kinetic Model of Circadian Oscillations. 1993-08-08 - 1993-08-13.