Et profilbilde

Førsteamanuensis
Kåre Bredeli Jørgensen { "honorific-suffix": "Førsteamanuensis", "fn": "Kåre Bredeli Jørgensen", "tel": "Telefon: 5183 2306", "email": "kare.b.jorgensen@uis.no" }

Avdeling/enhet Det teknisk- naturvitenskapelige fakultet
Institutt/senter Institutt for matematikk og naturvitenskap
Rom KE C-223

Undervisning:
KJE200 Organisk kjemi
MLJ540 Instrumentell analyse
ING140 Innføringsemne -kjemiingeniør

Forskningsområder

Forskningsområdet mitt er syntetisk organisk kjemi.

Jeg lager biologisk akive molekyler (potensiell medisin),
og metabolitter av polycycliske aromatiske hydrokarboner (PAHer) til bruk i miljøforskning og som miljøstandarder.

Utvalgte publikasjoner

  1. T. Böhme, M. Lorentzen and K. B. Jørgensen*, ?Regiospesific synthesis of dimethylphenanthrenes?, Polycyclic aromatic compounds, in print

  2. M. Lorentzen, A. Bayer, M.O. Sydnes*, K.B. Jørgensen*, «Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions?, Tetrahedron 71 (43), 8278-8284 (2015)

  3. K.B. Jørgensen*, T. Rantanen, Dörfler, T. and V. Snieckus*, ?Directed metalation_Suzuki-Miyaura Cross-Coupling Strategies: Regioselective Synthesis of Hydroxylated 1-Methyl-phenanthrenes?, J. Org Chem. 80 (19), 9410-9424 (2015)

  4. M. Lorentzen, M.O. Sydnes and K.B. Jørgensen*, ?Enantioselective Synthesis of (-)-(1R,2R)-1,2-dihydrochrysene-1,2-diol?, Tetrahendron 70, 9041-9051 (2014)

  5. M.F. Mady*, E.A. Ghada, K.B. Jørgensen*, ?Ultrasound-assisted synthesis of novel 1,2,3-triazoles coupled diaryl sulfone moieties by the CuAAC reaction, and biological evaluation of them as antioxidant and antimicrobial agents?, Eur. J. Med. Chem. 84, 433-443 (2014)

  6. K. B. Jørgensen*, ?Photochemical Oxidative Cyclization of Stilbenes and Stilbenoids ? The Mallory reaction?, Molecules 15, 4334-4358 (2010)

  7. K. B. Jørgensen*, M. Joensen, ?Photochemical synthesis of chrysenols?, Polycyclic aromatic compounds, 28 (4-5), 362-372 (2008)









Pågående forskning



Apart from a number of stray collaboration projects, the focus in my group have been synthesis of small ring PAHs and PAH metabolites as environmental standards and for exposure studies through collaborations.  Photochemical synthesis of chrysenes and phenanthrens through the Mallory reaction has engaged about 20 bachelor students in their projects the last 10 years. The more complicated route through directed metalation chemistry involving directed remote metalation to form phenanthrene scaffolds allow access to substitution patterns not available through the photochemical route.  This research has evolved into studies of directed ortho-metalation on the chrysene scaffold and will continue into studies of remote metalation on small PAHs for CH-activation and further functionalization, but also into synthesis of larger ring systems.


A second interest involve synthesis of biologically active molecules, and my group is involved in some national collaborations in synthesis of marine natural products and analogs for biological testing.



Arbeidserfaring

2008:   Visiting professor at V. Snieckus group, Queen?s University,
            Canada   (NFR?s Leiv Erikson-grant)

 

2000-:  Associate Professor at Department of Mathematics and

            Natural Science, Faculty of Science and Technology,

            University of Stavanger

 

1999:    Post doctoral research. at Department of Chemistry, 

             University of Bergen

 

1998:    Post doctoral research at Department of Chemistry,

            University of Tromsø

 

1995-97:  STA-fellow (Post doctoral research.) at Organic Chemistry

             Laboratory, The Institute of Physical and Chemical

             Research (RIKEN), Wakoshi (Tokyo), Japan

 

1995:    Dr. Ing. (Ph.D) in Organic Chemistry, Norwegian University

             of Science and Technology (NTNU)

 

1992-95:  Graduate research at NTNU: Personal grant from NAVF/NFR

1991-92:  Scientific assistant at the Organic Chemistry Laboratories at NTNU.

1990-91:Mandatory service in the navy: The Oil laboratory at the

Naval Supply Command, Haakonsvern, Bergen.

1990:Sivilingeniør (Master) in Organic Chemistry, NTNU,

1989-90: The Master-thesis NTNU, performed at Southwest State

University, Marshall, Minnesota: ?Oxidation of Alcohols with

Potassium Chlorochromate?.

Vitenskapelige publikasjoner (fra CRISTin)

  • Jørgensen, Kåre B.; Lillo, Cathrine (2005). First International Workshop on Growing Plants for Increased Nutritional Value. Universitetet i Stavanger. ISBN 8276442692. 38 s.
  • Jørgensen, Kåre Bredeli (2016). Biofuel. i/o/lab - Senter for Framtidskunst; 2016-03-13.
  • Jørgensen, Kåre Bredeli (2016). Intervju om Nobelprisen i kjemi, 2016. Scansat radio. [Radio]; 2016-10-07.
  • Jørgensen, Kåre Bredeli (2016). Molekylære maskiner – pH heis og verdens minste bil. Norsk kjemisk selskap, Rogaland avdeling; 2016-11-25.
  • Jørgensen, Kåre Bredeli (2016). Synthesis of functionalized PAHs by directed metalations. COST-action CA15106 (CHAOS); 2016-09-26 - 2016-09-28.
  • Jørgensen, Kåre Bredeli (2016). Synthesis of functionalized PAHs by photochemical cyclization and/or directed metalation strategies. Federal University of Rio de Janeiro, Laboratory of Integrat; 2016-08-11.
  • Jørgensen, Kåre Bredeli (2016). Synthesis of functionalized PAHs by photochemical cyclization and/or directed metalation strategies. Instituto de Quimica, Universidade Federal Do Rio De Janeiro; 2016-07-12.
  • Kancherla, Sindhu; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Snieckus, Victor (2016). Directed ortho metalation on larger aromatic systems. Elsevier; 2016-06-28 - 2016-07-01.
  • Kancherla, Sindhu; Lorentzen, Marianne; Snieckus, Victor; Jørgensen, Kåre Bredeli (2016). Directed metalation on larger aromatic systems. IIT Bombay; 2016-12-11 - 2016-12-16.
  • Kancherla, Sindhu; Lorentzen, Marianne; Snieckus, Victor; Jørgensen, Kåre Bredeli (2016). Directed ortho metalation on larger aromatic systems. Latvian Institute of Organic Synthesis; 2016-07-03 - 2016-07-06.
  • Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (2016). Total Synthesis of Tubastrine and 3-Dehydroxy Tubastrine. Universitetet i Tromsø; 2016-01-07 - 2016-01-10.
  • Pampanin, Daniela M.; Kemppainen, Eeva; Skogland, Karianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav (2016). Investigation of fixed wavelength fluorescence results for biliary metabolites of polycyclic aromatic hydrocarbons formed in Atlantic cod (Gadus morhua).
  • Sydnes, Magne Olav; Lindback, Emil; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Bayer, Annette (2016). Synthesis of Antimicrobial Natural Products and their Analogues – Martinelline and Tubastrine. 2016-06-16 - 2016-06-18.
  • Jørgensen, Kåre Bredeli (2015). Photochemical synthesis of substituted chrysenes and phenanthrenes. Universite de Bordeaux; 2015-09-13 - 2015-09-17.
  • Jørgensen, Kåre Bredeli (2015). Photochemical synthesis of substituted chrysenes and phenanthrenes.. Dep. of Plant and Environmental Sciences v/Jan Christensen; 2015-12-10.
  • Jørgensen, Kåre Bredeli; Lorentzen, Marianne; Bøhme, Thomas Andre (2015). Regiospesific synthesis of dimethylphenanthrenes. Universite de Bordeaux; 2015-09-13 - 2015-09-17.
  • Lorentzen, Marianne; Kalvet, Indrek; Sauriol, Francoise; Rantanen, Toni; Jørgensen, Kåre Bredeli; Snieckus, Victor (2015). The rotational Barriers of ortho-aryl benzamides and ortho-aryl naphtamides. Norsk kjemisk selskap, faggruppe for organisk kjemi; 2015-01-08 - 2015-01-11.
  • Lorentzen, Marianne; Kemppainen, Eeva; Pampanin, Daniela M.; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav (2015). Enantioselective total synthesis of trans-1,2-diol metabolites of 3- and 4-ring PAHs. 2015-01-08 - 2015-01-11.
  • Böhme, Thomas A; Lorentzen, Marianne; Jørgensen, Kåre Bredeli (2014). Regiospesific Synthesis of Dimethylphenanthrenes. Norsk Kjemisk Selskap - Faggruppe for Organisk Kjemi; 2014-01-09 - 2014-01-12.
  • Jørgensen, Kåre Bredeli; Böhme, Thomas A; Egeland, Mari; Lorentzen, Marianne; Mady, Mohamed F.; Solbakk, Michelle; Sæbø, Krister Samsonsen (2014). Regiospesific Photochemical Synthesis of Methylchrysenes. Norsk Kjemisk Selskap - Faggruppe for Organisk Kjemi; 2014-01-09 - 2014-01-12.
  • Jørgensen, Kåre Bredeli; Mady, Mohamed F.; Nilsen, Lyudmyla (2014). Ultrasound-assisted synthesis of novel 1,23-triazole coupled diaryl sulfone moieties by in situ formed azides in the CuAAC reaction. Universidade Nova De Lisboa; 2014-09-15 - 2014-09-17.
  • Lorentzen, Marianne; Kamppainen, Eeva; Pampanin, Daniela M.; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav (2014). Enantioselective total synthesis of trans-1,2-diol metabolites of 3 and 4-ring PAHs. 2014-06-29 - 2014-07-04.
  • Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (2014). Organisk kjemisk vintermøte 2015: OKV30.
  • Sydnes, Magne Olav; Skogland, Karianne; Marcucci, Cristian; Lorentzen, Marianne; Øysæd, Kjell Birger; Jørgensen, Kåre Bredeli; Larssen, Eivind; Bagi, Andrea; Pampanin, Daniela M. (2014). Indicator for Environmental Impact of Petroleum Activities: The Next Generation of Molecular Markers (iNEXT). IRIS; 2014-10-22 - 2014-10-24.
  • Jørgensen, Kåre (2013). Instrumentell analyse ved kjemilaboratoriene på UiS. Kjemigruppen UiS; 2013-01-07.
  • Jørgensen, Kåre (2013). Instrumentell analyse ved kjemilaboratoriene ved UiS. Kjemigruppen ved UiS; 2013-01-07.
  • Jørgensen, Kåre (2013). Instrumentell analyse ved kjemilaboratoriene ved UiS. Kjemigruppen, IMN; 2013-01-25.
  • Jørgensen, Kåre (2013). Kjernemagnetisk resonans (NMR). Universitetet i Stavanger; 2013-11-13.
  • Jørgensen, Kåre; Böhme, Thomas A; Egeland, Mari; Mady, Mohamed F.; Solbakk, Michelle; Sæbø, Krister Samsonsen (2013). Regiospesific photochemical synthesis of methylchrysenes. ISPAC; 2013-09-08 - 2013-09-12.
  • Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre (2013). Total Synthesis of (1R, 2R)-1,2-dihydrochrysene-1,2-diol. Norsk kjemisk selskap, fagruppe for organisk kjemi; 2013-01-10 - 2013-01-13.
  • Mady, Mohamed F.; Jørgensen, Kåre (2013). Ultrasound-assisted synthesis of mono and bis-1,2,3-triazoles containing sulfonyl dibenzene groups by 1,3-dipolar cycloaddition reaction. Norsk kjemisk selskap, faggruppe for organisk kjemi; 2013-01-10 - 2013-01-23.
  • Malmquist, Linus M V; Seleck, Henriette; Jørgensen, Kåre; Christensen, Jan H (2013). Aromatic acids are the main metabolites of sediment associated methylated PAHs exposed to the bentic invertebrate Nereis Diversicolor. ISPAC; 2013-09-08 - 2013-09-12.
  • Jørgensen, Kåre (2012). Da alkymi ble til kjemi. Norsk kjemisk selskap, avd. Rogaland; 2012-11-01.
  • Jørgensen, Kåre (2012). Fettsyrer: fra omega-3 til biodiesel. 2012-04-14.
  • Jørgensen, Kåre; Heggheim, Morten; Simonova, Anna; Mæland, Yngve; Toftegård, Oscar L. A. (2012). Photochemical Synthesis of 3-Nitrophenanthrene. Norsk kjemisk selskap, faggruppe for organisk kjemi; 2012-01-12 - 2012-01-15.
  • Jørgensen, Kåre; Rantanen, Tony; Snieckus, Victor (2012). Synthesis of methylphenanthrene metabolites by directed metalation - Suzuki cross coupling strategies. 2012-07-01 - 2012-07-04.
  • Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre (2012). A general chiral building-block for the asymmetric synthesis of PAH-metabolites. Norsk kjemisk selskap, faggruppe for organisk kjemi; 2012-01-12 - 2012-01-15.
  • Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre (2012). Total synthesis of (1R,2R)-1,2-dihydrochrysene-1,2-diol. 2012-07-01 - 2012-07-04.
  • Mady, Mohamed F.; El-Kateb, Ahmed A.; Zeid, Ibrahim F.; Jørgensen, Kåre (2012). Ultrasound-Assisted synthesis of Novel Homoallylic Alcohol Derivatives Containing The Sulphone Moiety in Aqueous Media. Umm Al Qura University; 2012-04-16 - 2012-04-18.
  • Jørgensen, Kåre Bredeli (2011). Fettsyrer: Fra omega-3 til biodiesel. Forskningsdagene 2011, Stavanger;
  • Jørgensen, Kåre Bredeli (2011). Landsmøte i Kjemi - Organisk kjemi.
  • Jørgensen, Kåre Bredeli (2011). Nobelprisen i Kjemi 2010: Om hvordan en kan snekre molekyler og mulighetene det gir. Vitenskapsakademiet i Stavanger;
  • Jørgensen, Kåre Bredeli (2011). Nobelprisen i kjemi 2010. NKS, Rogaland;
  • Jørgensen, Kåre Bredeli (2011). The 2010 Nobel Prize in Chemistry: Efficient assembling of useful molecules for medicines and cell-phone displays. Univeritetet i Stavanger;
  • Jørgensen, Kåre Bredeli; Heggheim, Morten; Simonova, Anna; Mæland, Yngve; Toftegård, Oscar L. A. (2011). Photochemical Synthesis of 3-Nitrophenanthrene. ISPAC/University of Münster; 2011-09-04 - 2011-09-08.
  • Lorentzen, Marianne; Jørgensen, Kåre Bredeli (2011). A general chiral building-block for the asymmetric synthesis of PAH-metabolites. NKS-FOK; 2011-01-06 - 2011-01-09.
  • Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (2011). A General Building-Block for the Asymmetric synthesis of PAC Metabolites. ISPAC/University of Münster; 2011-09-04 - 2011-09-08.
  • Jørgensen, Kåre B.; Melnes, Silje; Strand, Ragnhild Beate; Jakobsen, martin Gjerde; Jacobsen, Øyvind; Langseth, Eirin; Rosenberg, marianne (2010). Hurra, vi skal på internasjonal konferanse! Til Bergen? 18th Internasjonal Conference on organic Synthesis, 1-6 Aug 2010, Bergen.
  • Jørgensen, Kåre B.; Rantanen, Tony; Dörfler, Thilo; Snieckus, Victor (2009). Synthesis of 1-Methylphenanthrene Metabolites by Directed Metalation and Suzuki Cross Coupling Strategies. 2009-09-20 - 2009-09-24.
  • Jørgensen, Kåre B.; Rantanen, Tony; Dörfler, Thilo; Snieckus, Victor (2009). Synthesis of methylphenanthrene metabolites by directed metalation-Suzuki cross coupling strategies. 2009-01-08 - 2009-01-11.
  • Jørgensen, Kåre B.; Rantanen, Tony; Snieckus, Victor (2009). Synthesis of 1-methylphenanthrene Metabolites by Directed metalation Strategies. 2009-05-30 - 2009-06-30.
  • Nilsen, Lyudmyla Berg; Fessner, Wolf-Dieter; Jørgensen, Kåre B. (2009). C-Alkylation of Aldoses with the Indium-mediated Barbier-reaction. 2009-01-08 - 2009-01-11.
  • Jørgensen, Kåre B. (2008). The 21st International Symposium for Polycyclic Aromatic Compounds.
  • Jørgensen, Kåre B.; Nilsen, Lyudmyla Berg (2007). A Catalytic system for the indium-mediated Barbier-reaction. 2007-01-11 - 2007-01-14.
  • Jonsson, Grete; Jørgensen, Kåre B. (2005). Synthesis of hydroxychrysenes, and their use as standards in environmental monitoring. 2005-01-13 - 2005-01-16.
  • Jørgensen, Kåre B. (2005). Synthesis of hydroxychrysenes. 2005-08-21 - 2005-08-26.
  • Joensen, Majbritt; Jørgensen, Kåre B. (2003). Photochemical Synthesis of Chrysene Metabolites. 2003-01-09 - 2003-01-12.
  • Jørgensen, Kåre B.; Hatlestad, Arne Christian; Heggø, Anne-Lise; Lloyd, Robert Andrew; Veire, Fredrik Hagir (2003). Photochemical synthesis and fluorescence properties of monofluorinated hydroxychrysenes. 2003-09-21 - 2003-09-25.
  • Jørgensen, Kåre B. (2002). Grønn kjemi. Høgskolen i Stavanger, Avdeling for teknisk- naturvitenskapelige fag; 2002-04-25.
  • Jørgensen, Kåre B; Gautun, Odd R (2000). Efficient Stereoselective Preparation of Protected Isodityrosines.