Et profilbilde

Førsteamanuensis
Astrid Elisabeth Mork-Jansson { "honorific-suffix": "Førsteamanuensis", "fn": "Astrid Elisabeth Mork-Jansson", "tel": "Telefon: 51831886", "email": "astrid.mork-jansson@uis.no" }

Avdeling/enhet Det teknisk- naturvitenskapelige fakultet
Institutt/senter Institutt for kjemi, biovitenskap og miljøteknologi
Rom I8 D-213

Forskningsområder

Characterization of exosomes, drug delivery accross the blood-brain barrier and intractable epilepsy.
Characterization of LIL3 and the proteins function in chlorophyll synthesis.
https://morkjansson.com/



Utvalgte publikasjoner

Mork-Jansson, A. E and Eichacker, L. A, A strategy to characterize chlorophyll protein interaction in LIL3. Plant Methods, 2019. DOI 10.1186/s13007-018-0385-5

Lille-Langoy, R. Karlsen, O. A. Myklebust, L. M. Goldstone, J. V. Mork-Jansson, A. Male, R. Blumberg, B. Stegeman, J. J. and Goksoyr, A. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicological Sciences, 2018, DOI 10.1093/toxsci/kfy269

Mork-Jansson, A.E. and Eichacker L.A, Characterization of chlorophyll binding to LIL3. PLOS ONE, 2018, DOI 10.1371/journal.pone.0192228

Mork-Jansson, A., Gargano, D., Kmiec, K., Furnes, C., Shevela, D. and Eichacker, L.,. Lil3 dimerization and chlorophyll binding in Arabidopsis thaliana. FEBS Letters, 2015 DOI 10.1016/j.febslet.2015.08.023

Mork-Jansson, A., Bue, A. K., Gargano, D., Furnes, C., Reisinger, V., Arnold, J., Kmiec, K. and Eichacker, L. A.. Lil3 Assembles with Proteins Regulating Chlorophyll Synthesis in Barley. PLOS ONE 2015, DOI 10.1371/journal.pone.0133145

Pågående forskning

My research project:
Delivery of therapeutics accross the blood-brain barrier is challanging due to high selectivity of the barrier. My objective is to establish a trafficing system based on exosomes to enable treatment of brain disease, specifically intractable epilepsy.
Methods applied in the research project are: Chromatography, confocal microscopy, mass spectrometry, isolation of primary cells, a blood-brain barrier model and an in vivo mouse model.


Prof Dr Lutz Eichackers research project:
My focus in this project is to contribute to the characterization of the light-harvestig like protein 3 (LIL3). Protein-preotein interactions between the enzymes chlorophyll synthase, protochlorophyllide oxidoreductase and geranylgeranyl reductase and the protein LIL3 has been analyzed in detail. In addition a great effort has been put in to characterize pigment binding to LIL3.
Methods I have applied in the research project are: Cloning, protein purification, microscale thermophoresis, surface plasmon resonance, reconstitution assays, free flow electrophoresis and nanoDSF.

Prof. Dr. Anders Goksøyrs research project:
My recent participation in this project was the finalization of the 2018 publication in toxocological sciences where some of my findings during my master thesis work was published.
Methods I applied to obtain published data: Cloning and luciferase reporter assays

Arbeidserfaring

2019-present Senior lecturer, Bioinformatics, UiS
2015- present Postdoctoral Fellowship, UiS2011-2015, PhD Candidate, UiS
2015-2015 Senior Lecturer, Protein biochemistry, UiS
2011-2011 Senior Lecturer, General Sciences, Akademiet Sandnes
2011-2011 Senior Lecturer Mixed subjects, Riska Ungdomskole

Vitenskapelige publikasjoner (fra CRISTin)

  • Jakubec, Martin; Halskau, Øyvind; Janigro, Damir; Mork-Jansson, Astrid Elisabeth (2018). A novel exosome-like nanocarrier for treatment of refractory epilepsy. EU; 2018-05-24 - 2018-05-25.
  • Jakubec, Martin; Halskau, Øyvind; Janigro, Damir; Mork-Jansson, Astrid Elisabeth (2018). A novel exosome-like nanocarrier for treatment of refractory epilepsy. epiXchange, EU;
  • Jakubec, Martin; Halskau, Øyvind; Mork-Jansson, Astrid Elisabeth (2018). A novel exosome-like nanocarrier for treatment of refractory epilepsy. 2018-06-16 - 2018-06-22.
  • Eichacker, Lutz Andreas; Mork-Jansson, Astrid Elisabeth; Bue, Ann Kristin; Gargano, Daniela; Arnold, Janine; Reisinger, Veronika; Kmiec, Karol; Furnes, Clemens; Shevela, Dmitriy (2016). Chlorophyll binding to light-harvesting-like protein 3. Thorsten Hamann; 2016-06-15 - 2016-06-17.
  • Eichacker, Lutz Andreas; Mork-Jansson, Astrid Elisabeth; Gargano, Daniela; Bue, Ann Kristin; Arnold, Janine; Reisinger, Veronika; Furnes, Clemens (2016). Lil3 and the protein’s function in chlorophyll synthesis.. Poul Erik Jensen; 2016-10-25 - 2016-10-28.