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Advanced Organic Chemistry (MLJ550)

In MLJ550 the students gain advanced knowledge in synthetic organic chemistry and stereochemistry.


Course description for study year 2022-2023. Please note that changes may occur.

Facts
Course code

MLJ550

Version

1

Credits (ECTS)

10

Semester tution start

Spring

Number of semesters

1

Exam semester

Spring

Language of instruction

English

Content

The students will learn to build complex molecules through carbon-carbon bond creating reactions like the classical Aldol reaction, Claisen condensation, and pericyclic reactions (e.g. the Diels-Alder reaction), but also modern Pd-catalyzed cross-coupling reactions like Suzuki Miyaura, Heck, and Negishi reactions (the 2010 Nobel prize in chemistry). Such reactions are useful tools in organic synthesis for carbon-carbon bond creation.

Functionalization of aromatic compounds are covered through nucleophilic and electrophilic aromatic substitution reactions in addition to the Sandmeyer reaction. These types of reactions are useful for the synthesis of coupling partners in the abovementioned palladium catalyzed cross-coupling reactions. The students will be educated in various oxidation and reduction reactions for organic compounds with emphasis on selectivity and sustainability.

Throughout the course the students will apply a mechanistic approach to understand the outcome of chemical reactions, including stereoselectivity, and use frontier orbital theory as a tool.

Laboratory course

The course includes 1 to 2 weeks of mandatory laboratory exercises with the grading system passed or not passed. Here the students will learn experimental methodology for organic synthesis, plan their experiments and apply some of the theory in practice. The results obtained in the laboratory is presented in written reports. 

Learning outcome
  • Be able to suggest reagents and reactions for desired organic transformations.
  • Be able to describe organic chemical reactions by using the frontier orbital theory.
  • Be able to suggest reaction pathways for multi-step organic synthesis.
  • Be able to set up synthetic organic experiments, perform a short sequence of transformations and characterize the products.
Required prerequisite knowledge
KJE200 Organic Chemistry 1
Exam
Form of assessment Weight Duration Marks Aid
Written exam 1/1 4 Hours Letter grades

Coursework requirements
Mandatory laboratory course

The mandatory lab course shall be completed at the times and in the groups that are assigned and published. Valid absence due to illness or other reasons must be communicated as soon as possible to teaching staff. In cases of valid absence, it may be possible to complete the lab at other times, where agreed with the teaching staff. This is not an entitlement. 

If a student wishes to redo the lab, this can be done next time the subject is taught. 

Course teacher(s)
Course coordinator: Emil Anders Lindbäck
Head of Department: Ingunn Westvik Jolma
Method of work
4 hours lectures with exercises 2 days per week and 1-2 two weeks of laboratory exercises.
Overlapping courses
Course Reduction (SP)
Advanced Organic Chemistry (MET250_1) 10
Organic chemistry II (MOT180_2) 10
Organic chemistry 2 (TE6050_1) 6
Organic chemistry 2 (TE6050_A) 6
Organic chemistry II (MOT180_1) 5
Open for
Biological Chemistry, Master of Science Degree Programme Environmental Engineering, Master of Science Degree Programme Exchange programme at Faculty of Science and Technology
Course assessment
Usually by forms and/or discussion according to university regulations.
Literature
Search for literature in Leganto