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Nobel-prisen fysiologi 2014 – foredrag om hjernens navigasjonssystem

David Clayton Rowland, nevroforsker fra NTNU, holder foredrag om hjernens navigasjonssystem og hva denne oppdagelsen kan bety.

Norges Tekniske Vitenskapsakademi (NTVA) og Vitenskapsakademiet i Stavanger inviterer til åpent møte på Arkeologisk museum i Stavanger. 

Foredragsholder er David Clayton Rowland, postdoc ved Kavli Institute of Systems Neuroscience, NTNU. Foredraget holdes på engelsk.

Om foredraget:

The hippocampus has fascinated neuroscientists for more than a century. The first modern neuroanatomists, working near the turn of the 20th century, were drawn to the beautiful architecture of the structure. In the middle of the 20th century, Scoville and Milner reported that removal of the hippocampus produced startling memory impairments in humans.

Against this background, John O’Keefe began recording from single neurons in the hippocampus of awake behaving rats in the early 1970’s. Surprisingly, he discovered that the neurons responded to the animal’s location in the environment, and he therefore called the cells “place cells.”

Roughly 30 years later, Edvard and May-Britt Moser discovered “grid cells” in the entorhinal cortex, the major input to the hippocampus. Unlike place cells, grid cells have multiple firing fields that form a lattice over the environment, similar to the longitude and latitude lines on a map.

Today we believe that grid cells and place cells together constitute the core of the brain’s navigational system. In this talk, I will review these seminal findings and discuss major unanswered questions, including how grid cells and place cells might relate to memory.