This research group focuses on exploring and implementing green and sustainable chemistry into novel biodegradable and non-toxic compounds.
The Mady research group is mainly focused on these themes:
- Green organic synthesis (Theme Coordinator: Dr. Mohamed F. Mady)
- Sustainable energy chemistry (Theme Coordinators: Prof. Dr. Malcolm A. Kelland and Dr. Mohamed F. Mady)
Our research group concentrates on developing new approaches to the synthesis of environmentally-friendly materials. We have used key enabling technologies, including microwave irradiation, sonochemistry, mechanochemistry, solventless reactions, and catalysis. In general, we have developed a series of new products for different applications, particularly for oilfield and medical applications.
Particular research areas of interest include:
Bioactive compounds for medical applications
Antimicrobial agents are fundamental medicines for humans and animal health. These inhibitors are considered miracle drugs to treat infections caused by bacteria, fungi, parasites, and viruses. According to the World Health Organization (WHO), resistant microorganisms often fail to respond to conventional treatment, resulting in prolonged illness and greater death risk.
In this regard, we have made significant contributions to the development of new antioxidant and antimicrobial agents. We have synthesized a series of 1,2,3-triazoles coupled diaryl sulfone moieties by the CuAAC reaction in benign solvents under ultrasound irradiation as promising antifungal, antioxidant, and antimicrobial agents (Eur. J. Med. Chem. 2014, 12, 433-443).
Furthermore, we have developed novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety under microwave irradiation as potential antimicrobial agents (Res. Chem. Intermed. 2016, 42, 753-769).
We have also synthesized and investigated a series of novel pyrazolo[1,5-a]pyrimidines and pyrazole-indole hybrids as anticancer agents. The new compounds were screened for their in vitro antitumor activity toward liver (HepG-2) and breast (MCF-7) human cancer cells using 3-[4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide MTT assay (Chin. Chem. Lett. 2017, 28, 388-393, and ACS Omega, 2021, Under review). The results showed that most compounds gave dose-dependent cytotoxic activities against all cancer types (liver and breast cancer) than reference cytotoxic compounds.
Moreover, we are currently exploring new biodegradable and non-toxic chemicals for kidney stone prevention, particularly for calcium oxalate (Cryst. Growth Des. 2018, 18, 7441−7450).
Biodegradable materials for oilfield applications
Despite a global move towards more renewable energy sources, oil and gas production will also continue for many decades. During the production phase of oil, many chemicals are added to the well stream to prevent a range of problems such as corrosion and flow line deposits such as gas hydrates, scale, wax, and asphaltenes.
The oil and gas industry has strived for many years to develop green chemicals that have little or no acute and chronic environmental impact. Our main research group objective is to investigate the development of environmentally-friendly chemicals to prevent oilfield flow assurance problems.
Researchers in the Sustainable Energy Chemistry Group are studying and developing a series of biodegradable materials for gas hydrate and scale inhibition in the upstream oil and gas industry. In collaboration with Total, Norge, we have designed and synthesized novel classes of non-toxic and biodegradable organophosphorus scale inhibitors against oilfield scales, particularly for calcium carbonate (calcite) and barium sulfate (barite) scales (Ind. Eng. Chem. Res. 2020, 59, 9808−9818), and ACS Omega 2021, 6, 6488−6497.
The Mady Group seeks to develop a novel sustainable processing technology-based environmental nanomaterial for removing production chemicals from produced fluids. In collaboration with global national and international partners, we will investigate for the first time the use of revolutionary environmental nanotechnology to prevent oilfield flow assurance problems. This method is unique as it will give ZERO an environmental impact from oilfield operations (ACS Appl. Nano Mater. 2020, 3, 7343−7364). We are also currently synthesizing and developing new green nanomaterials for various applications, including biomedical and catalysis.
This research is supported by the Research Council of Norway and collaborations with Professor Jamie Lead, Director of the Smart State Center for Environmental Nanoscience and Risk (CENR), Professor of environmental nanoscience and risk at the University of South Carolina, Columbia, USA. General information about this project is available on the Research Council of Norway Website.
Ali Alkaraly, PhD student
Abd El-Rahman AboZied, PhD student
Rocio Ortega, Master student
Alaa Suliman, Bachelor student
Eirik Haukereid, Bachelor student
Professor Jamie Lead, University of South Carolina, Columbia, USA.
Professor Salima Baraka-Lokmane, Total, Paris (Pau), France.
Professor Naglaa M. Abdelrahman, National Research Centre, Giza, Egypt.