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Hanne Røland Hagland

Førsteamanuensis i Biomedisin, Leder av forskningsnettverk for helse og teknologi

Det teknisk- naturvitenskapelige fakultet
Institutt for kjemi, biovitenskap og miljøteknologi
I8 D-112

My research interest area is cancer cell metabolism. Cancer cells can be highly hetereogenous with regards to gene profile, but still have a common ability to adapt and grow in harsh growth environment. We are interested in studying the mitochondrial contribution to growth adaptation in cancer cells and how this influence cancer treatment response. We are working in close collaboration with clinicians in the field of translational oncology, adapting protocols to real patient samples to give more targeted treatment to cancer patients. Our lab facilities entails state of the art equipment for studying cell gene expression, protein analysis and metabolic flux measurements. 

I have been fortunate to lead a research network connecting people from different expertise areas to collaborate on solving health challenges. I am always interested in new collaborations and thrive in learning about new technologies to see how they can be used in our search for a better life.

  • Vitenskapelige publikasjoner
    • Alhourani, Abdelnour; Førde, Jan-Lukas; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland


      Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide.

      ACS Omega

      ISSN 2470-1343.

      Volum 6.

      Hefte 38.


      DOI: 10.1021/acsomega.1c03283

    • Lea, Dordi; Watson, Martin Matthew Christian; Skaland, Ivar; Hagland, Hanne Røland; Lillesand, Melinda; Gudlaugsson, Einar; Søreide, Kjetil


      A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment.

      Cancer Immunology and Immunotherapy

      ISSN 0340-7004.

      Volum 70.


      DOI: 10.1007/s00262-020-02834-y

    • Alhourani, Abdelnour; Tidwell, Tia; Bokil, Ansooya Avinash; Røsland, Gro V.; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne R.


      Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells.

      Scientific Reports

      ISSN 2045-2322.

      Volum 11.

      Hefte 1.


      DOI: 10.1038/s41598-021-89861-6

    • Watson, Martin Matthew Christian; Lea, Dordi; Gudlaugsson, Einar; Skaland, Ivar; Hagland, Hanne Røland; Søreide, Kjetil


      Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer.

      Cancer Immunology and Immunotherapy

      ISSN 0340-7004.

      Volum 69.


      DOI: 10.1007/s00262-020-02573-0

    • Watson, Martin; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil


      Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots.

      Translational Oncology

      ISSN 1944-7124.

      Volum 12.

      Hefte 12.


      DOI: 10.1016/j.tranon.2019.08.009

    • Watson, Martin; Kanani, Arezo; Lea, Dordi; Khajavi, Ramesh Batol; Søreide, Jon Arne; Kørner, Hartwig; Hagland, Hanne Røland; Søreide, Kjetil


      Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST) in Colorectal Cancer is Associated with an Elderly, Frail Phenotype and Improved Recurrence-Free Survival.

      Annals of Surgical Oncology

      ISSN 1068-9265.

      DOI: 10.1245/s10434-019-08048-6

    • Talasila, Krishna Mukharji; Røsland, Gro Vatne; Hagland, Hanne Røland; Eskilsson, Eskil; Flønes, Irene Hana; Fritah, Sabrina; Azuaje, Francisco; Atai, Nadia A; Harter, Patrick N.; Mittelbronn, Michel; Andersen, Michael Borenste; Vareecal Joseph, Justin; Hossain, Jubayer; Vallar, Laurent; van Noorden, Cornelis J.F.; Niclou, Simone Pierrette; Thorsen, Frits; Tronstad, Karl Johan; Tzoulis, Charalampos; Bjerkvig, Rolf; Miletic, Hrvoje


      The angiogenic switch leads to a metabolic shift in human glioblastoma.


      ISSN 1522-8517.

      Volum 19.

      Hefte 3.


      DOI: 10.1093/neuonc/now175

    • Hagland, Hanne Røland; Lea, Dordi; Watson, Martin Matthew Christian; Søreide, Kjetil


      Correlation of blood T-cells to intratumoural density and location of CD3+ and CD8+ T-cells in colorectal cancer.

      Anticancer Research

      ISSN 0250-7005.

      Volum 37.

      Hefte 2.


      DOI: 10.21873/anticanres.11363

    • Tidwell, Tia; Søreide, Kjetil; Hagland, Hanne Røland


      Aging, metabolism, and cancer development: From Peto's paradox to the Warburg effect.

      Aging and Disease

      ISSN 2152-5250.

      Volum 8.

      Hefte 5.


      DOI: 10.14336/AD.2017.0713

    • Aunan, Jan Rune; Watson, Martin Matthew Christian; Hagland, Hanne; Søreide, Kjetil


      Molecular and biological hallmarks of ageing.

      British Journal of Surgery

      ISSN 0007-1323.

      Volum 103.

      Hefte 2.


      DOI: 10.1002/bjs.10053

    • Søreide, Kjetil; Watson, Martin Matthew Christian; Lea, Dordi; Nordgård, Oddmund; Søreide, Jon Arne; Hagland, Hanne Røland


      Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): Study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis.

      Journal of Translational Medicine

      ISSN 1479-5876.

      Volum 14:192.

      DOI: 10.1186/s12967-016-0951-4

    • Watson, Martin Matthew Christian; Lea, Dordi; Rewcastle, Emma; Hagland, Hanne Røland; Søreide, Kjetil


      Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?.

      Cancer Medicine

      ISSN 2045-7634.

      Volum 5.

      Hefte 7.


      DOI: 10.1002/cam4.709

    • Søreide, Kjetil; Watson, Martin Matthew Christian; Hagland, Hanne Røland


      Deciphering the Molecular Code to Colorectal Liver Metastasis Biology Through Microsatellite Alterations and Allelic Loss: The Good, the Bad, and the Ugly.


      ISSN 0016-5085.

      Volum 150.

      Hefte 4.


      DOI: 10.1053/j.gastro.2016.02.060

    • Hagland, Hanne Røland; Søreide, Kjetil


      Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways..

      Cancer Letters

      ISSN 0304-3835.

      Volum 356.


      DOI: 10.1016/j.canlet.2014.02.026

    • Lea, Dordi; Håland, Sven; Hagland, Hanne; Søreide, Kjetil


      Accuracy of TNM staging in colorectal cancer: A review of current culprits, the modern role of morphology and stepping-stones for improvements in the molecular era.

      Scandinavian Journal of Gastroenterology

      ISSN 0036-5521.

      Volum 49.

      Hefte 10.


      DOI: 10.3109/00365521.2014.950692

    • Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Doskeland, Stein Ove


      Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

      PLOS ONE

      ISSN 1932-6203.

      Volum 9.

      Hefte 4.

      DOI: 10.1371/journal.pone.0094926

    • Berg, Marianne; Hagland, Hanne; Søreide, Kjetil


      Comparison of CpG island methylator phenotype (CIMP) frequency in colon cancer using different probe- and gene-specific scoring alternatives on recommended multi-gene panels.

      PLOS ONE

      ISSN 1932-6203.

      Volum 9.

      Hefte 1:e86657.

      DOI: 10.1371/journal.pone.0086657

    • Hagland, Hanne; Berg, Marianne; Jolma, Ingunn Westvik; Carlsen, Arne; Søreide, Kjetil


      Molecular Pathways and Cellular Metabolism in Colorectal Cancer.

      Digestive Surgery

      ISSN 0253-4886.

      Volum 30.

      Hefte 1.


      DOI: 10.1159/000347166

    • Hagland, Hanne; Hodneland, Linn I.; Burri, Lena; Nikolaisen, Julie; Berge, Rolf Kristian; Tronstad, Karl Johan


      Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA).

      Biochemical and Biophysical Research Communications - BBRC

      ISSN 0006-291X.

      Volum 430.

      Hefte 2.


      DOI: 10.1016/j.bbrc.2012.11.111

    • Erikstein, Bjarte Skoe; Hagland, Hanne; Nikolaisen, Julie; Kulawiec, Marion; Singh, Keshav K.; Gjertsen, Bjørn Tore; Tronstad, Karl Johan


      Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment.

      Journal of Cellular Biochemistry

      ISSN 0730-2312.

      Volum 111.

      Hefte 3.


      DOI: 10.1002/jcb.22741

    • Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell O.; Tronstad, Karl Johan; Johannessen, Anne Chr.; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore


      Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.

      Molecular Cancer

      ISSN 1476-4598.

      Volum 8.

      Hefte 101.

      DOI: 10.1186/1476-4598-8-101

    • Petersen, Rasmus Kofoed; Madsen, Lise; Pedersen, Lone Møller; Hallenborg, Philip; Hagland, Hanne; Viste, Kristin; Doskeland, Stein Ove; Kristiansen, Karsten


      Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.

      Molecular and Cellular Biology

      ISSN 0270-7306.

      Volum 28.

      Hefte 11.


      DOI: 10.1128/MCB.00709-07

    • Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn Iren; Gjertsen, Bjørn Tore; Bruserud, Øystein; Tronstad, Karl Johan


      Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling.

      Expert opinion on therapeutic targets

      ISSN 1472-8222.

      Volum 11.


      DOI: 10.1517/14728222.11.8.1055

  • Bøker og kapitler
    • Hagland, Hanne


      Cellular responses to metabolic stress – a study on the role of mitochondria in the crosstalk between cell metabolism and survival signalling.

      ISBN 978-82-308-2092-6.

    • Hagland, Hanne; Selheim, Frode; Keen, TJ; Skjærven, Kaja H; Christensen, Anne Elisabeth; Herfindal, Lars; Doskeland, Stein Ove


      The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis.

      ISBN 978-88-7587-113-0.

    • Hagland, Hanne; Selheim, Frode; Doskeland, Stein Ove


      Cyclic AMP dependent protein kinase (cAPK) and exchange protein directly activated by cAMP (Epac) signaling in Rat pheochromocytoma PC12 and Human Neuroblastma SH-SY5Y cell line.

  • Formidling
    • van der Giezen, Mark; Hagland, Hanne Røland; Berland, Unni


      På labben: UiS - Røland Hagland og van der Giezen.

    • Bokil, Ansooya; Alhourani, Abdelnour; Hagland, Hanne Røland; Tidwell, Tia


      The metabolic profile of cancer cells play a major role in their response to metformin.

    • Tidwell, Tia; Hagland, Hanne Røland


      Modeling the tumor microenvironment in a 3D microfluidic device with colorectal cancer spheroids.

    • Hagland, Hanne Røland; Tidwell, Tia


      Directed cell migration from a single spheroid culture in a small-molecule gradient.

    • Hagland, Hanne Røland


      Forskningsnettverk for helse og helseteknologi.

    • Hagland, Hanne Røland


      Tverrfaglig samarbeid – hva må til? .

    • Hagland, Hanne Røland; Tidwell, Tia


      Cancer cell migration and phenotype plasticity in the presence of a nutrient gradient.

    • Akerjordet, Kristin; Hagland, Hanne Røland; Aas, Randi Wågø; Viksveen, Petter; Oftedal, Bjørg Frøysland; Laugaland, Kristin Alstveit; Wiig, Siri


      How to Educate Young People to work With Public Health and Better Aging.

    • Tidwell, Tia; Hagland, Hanne Røland; Røsland, Gro Vatne; Tronstad, Karl Johan


      Metabolic profiling of Colorectal cancer in 3D.

    • Tidwell, Tia; Hagland, Hanne Røland


      Development of 3D cancer cell model to mimic in vivo growth conditions for discovery of metabolic biomarkers in cancer.

    • Hagland, Hanne Røland; Søreide, Kjetil; Lea, Dordi; Watson, Martin Matthew Christian


      Correlation of circulating T-cells in pre-operative blood to intratumoral density and location of CD3+ and CD8+ T-cells in colorectal cancer: a potential for an immunoscore by “liquid biopsy”? .

    • Alhourani, Abdelnour; Tidwell, Tia; Bokil, Ansooya; Hagland, Hanne Røland


      The effects of metformin treatment in colorectal cancer cells  of opposing metabolic phenotype.

    • Hagland, Hanne Røland


      Kreftceller endrer metabolisme etter vekstbehov.

    • Hagland, Hanne Røland


      Kreftbehandling ved bruk av immunterapi – gjennombruddet og begrensningene.

    • Hagland, Hanne


      Cancer Cell Metabolism.

    • Nikolaisen, Julie; Hodneland Nilsson, Linn I.; Røland Hagland, Hanne; Koopman, Werner JH; Tronstad, Karl Johan


      Mitochondrial function, biogenesis and morphology in cellular stress.

    • Nilsson, L I H; Nikolaisen, Julie; Hagland, Hanne; Tronstad, Karl Johan


      A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells.

      Biochimica et Biophysica Acta - Bioenergetics

      ISSN 0005-2728.

      Volum 1817.


      DOI: 10.1016/j.bbabio.2012.06.197

    • Nikolaisen, Julie; Nilsson Hodneland, Linn I.; Røland Hagland, Hanne; Koopman, Werner JH; Tronstad, Karl Johan


      Mitochondrial morphology and biogenesis in cellular stress.

    • Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn I.; Tronstad, Karl Johan


      Mitochondrial function in cancer cell line models.

      Biochimica et Biophysica Acta - Bioenergetics

      ISSN 0005-2728.

      Volum 1777.


      DOI: 10.1016/j.bbabio.2008.05.164

  • Kunstnerisk produksjon
    • Nilsen, Mari Mæland; Hagland, Hanne Røland


      Nysgjerrig molekylærbiolog.

  • Kommersialisering
  • Cristin hovedlogo, Cristin current research information system in Norway